Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 3/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.53 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17993499 | 0.82 | HDAC4 (0.53) | HDAC4HSD11B1AKR1C1SMN1; SMN2HTT | |
| SCHEMBL8572144 | 0.80 | HDAC4 (0.59) | HDAC4HSD11B1AKR1C1SMN1; SMN2HTT | |
| SCHEMBL1100195 | 0.80 | HDAC4 (0.59) | HDAC4HSD11B1AKR1C1SMN1; SMN2HTT | |
| SCHEMBL172001 | 0.79 | HDAC4 (0.50) | HDAC4HSD11B1AKR1C1SMN1; SMN2HTT | |
| SCHEMBL6628661 | 0.78 | HDAC1 (0.71) | HDAC4SMN1; SMN2HTTTHRBHDAC1 | |
| SCHEMBL14019859 | 0.77 | EPHX1 (0.56) | HDAC4HSD11B1SMN1; SMN2HTTTHRB | |
| SCHEMBL3116138 | 0.76 | AKR1C1 (0.61) | HDAC4HSD11B1AKR1C1SMN1; SMN2HTT | |
| SCHEMBL6391 | 0.76 | AKR1C1 (0.83) | HDAC4HSD11B1AKR1C1ALDH1A1HDAC9 | |
| SCHEMBL31016196 | 0.76 | AKR1C1 (0.83) | HDAC4HSD11B1AKR1C1ALDH1A1HDAC9 | |
| SCHEMBL2722768 | 0.76 | SMN1; SMN2 (0.59) | HDAC4HSD11B1AKR1C1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201580-A1 | PYRROLIDINE DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-08-18 | — | — | US | disclosed |
| WO-2011095535-A2 | PYRROLIDINE DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201580-A1 | PYRROLIDINE DERIVATIVES | IL5, TSLP, NR3C1 | HDAC4 1370/4885HSD11B1 38/4885AKR1C1 893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.