Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.51 |
| ▸ | MMEL1 | Q495T6 | 4/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.39 |
| ▸ | ITGAV | P06756 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12975086 | 0.90 | MMEL1 (0.59) | MMEMMEL1 | |
| SCHEMBL17751396 | 0.86 | MME (0.48) | MMEMMEL1CTSSCTSKATM | |
| SCHEMBL12975711 | 0.85 | MME (0.52) | MMEMMEL1CTSSCTSKATM | |
| SCHEMBL14952979 | 0.84 | MMEL1 (0.67) | MMEMMEL1 | |
| SCHEMBL12975100 | 0.84 | MMEL1 (0.67) | MMEMMEL1 | |
| SCHEMBL1912622 | 0.84 | CTSS (0.55) | MMEMMEL1CTSSCTSKATM | |
| SCHEMBL1912621 | 0.84 | CTSS (0.55) | MMEMMEL1CTSSCTSKATM | |
| SCHEMBL2779899 | 0.83 | MMEL1 (0.62) | MMEMMEL1 | |
| SCHEMBL2779890 | 0.83 | MMEL1 (0.62) | MMEMMEL1 | |
| SCHEMBL2865937 | 0.81 | CTSS (0.50) | CTSSCTSKATMCTSBKLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594557-B1 | Substituted aminopropionic derivatives as neprilysin inhibitors | NOVARTIS AG (CH) | 2016-08-10 | — | — | EP | disclosed |