Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 8/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 8/20 | 0.42 |
| ▸ | AVPR1B | P47901 | 8/20 | 0.38 |
| ▸ | OXTR | P30559 | 2/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.38 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1795727 | 0.97 | DRD2 (0.42) | DRD2ADRA1DADRA1AADRA1BAVPR1B | |
| Hydrochloric Acid SCHEMBL1796945 | 0.97 | DRD2 (0.41) | DRD2ADRA1DADRA1AADRA1BAVPR1B | |
| Hydrochloric Acid SCHEMBL1794245 | 0.95 | DRD2 (0.39) | DRD2ADRA1DADRA1AADRA1BAVPR1B | |
| SCHEMBL1799421 | 0.94 | DRD2 (0.41) | DRD2ADRA1DADRA1AADRA1BAVPR1B | |
| Hydrochloric Acid SCHEMBL1796763 | 0.94 | DRD2 (0.39) | DRD2ADRA1DADRA1AADRA1BAVPR1B | |
| SCHEMBL1797246 | 0.94 | KDM4E (0.41) | DRD2ADRA1DADRA1AADRA1BAVPR1B | |
| Hydrochloric Acid SCHEMBL1797583 | 0.92 | DRD2 (0.41) | DRD2ADRA1DADRA1AADRA1BAVPR1B | |
| SCHEMBL2076486 | 0.92 | DRD2 (0.38) | DRD2ADRA1DADRA1AADRA1BAVPR1B | |
| Hydrochloric Acid SCHEMBL1465079 | 0.91 | DRD2 (0.37) | DRD2ADRA1DADRA1AADRA1BAVPR1B | |
| SCHEMBL1795567 | 0.91 | ALDH1A1 (0.42) | DRD2ADRA1DADRA1AADRA1BAVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338590-B2 | Substituted oxindole derivatives and medicaments containing the same | ABBOTT GMBH & CO. KG (DE) | 2012-12-25 | — | — | US | disclosed |
| US-20110257194-A1 | SUBSTITUTED OXINDOL DERIVATIVES AND MEDICAMENTS CONTAINING THE SAME | ABBOTT GMBH & CO. KG (DE) | 2011-10-20 | — | — | US | disclosed |
| US-7951807-B2 | Substituted oxindol derivatives and medicaments containing the same | ABBOTT GMBH & CO. KG (DE) | 2011-05-31 | — | — | US | disclosed |
| US-20090005397-A1 | Substituted Oxindol Derivatives and Medicaments Containing the Same | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005397-A1 | Substituted Oxindol Derivatives and Medicaments Containing the Same | OXTR, AVPR2, AVPR1B | DRD2 46/4885ADRA1D 31/4885ADRA1A 59/4885 |
| US-20110257194-A1 | SUBSTITUTED OXINDOL DERIVATIVES AND MEDICAMENTS CONTAINING THE SAME | OXTR, AVPR2, AVPR1B | DRD2 39/4885ADRA1D 41/4885ADRA1A 71/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.