SCHEMBL17997262

SCHEMBL17997262

CCOc1ccc(Br)c(O)c1F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.39
HSD17B10 Q99714 2/20 0.39
LARS1 Q9P2J5 1/20 0.38
HPGD P15428 4/20 0.38
L3MBTL1 Q9Y468 3/20 0.37
TDP1 Q9NUW8 2/20 0.37
MAPT P10636 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
LMNA P02545 1/20 0.36
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C19 P33261 1/20 0.35
ERN1 O75460 1/20 0.35
POLB P06746 1/20 0.35
PDE4A P27815 1/20 0.35
PDE4B Q07343 1/20 0.35
PDE4C Q08493 1/20 0.35
PDE4D Q08499 1/20 0.35
KDM4E B2RXH2 1/20 0.35
MAPK1 P28482 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17997273 0.86 HPGD (0.42) HSD17B10HPGDMAPTSMN1; SMN2LMNA
SCHEMBL21823758 0.85 TSHR (0.39) TSHRHSD17B10LARS1HPGDL3MBTL1
SCHEMBL5093457 0.84 ESR1 (0.40) SMN1; SMN2LMNACYP1A2CYP2C19KDM4E
SCHEMBL30189397 0.84 HPGD (0.41) TSHRHSD17B10LARS1HPGDL3MBTL1
SCHEMBL1243244 0.84 HPGD (0.41) TSHRHSD17B10LARS1HPGDL3MBTL1
SCHEMBL28687675 0.82 NR5A1 (0.44) MAPTLMNAMEN1KMT2A
SCHEMBL1008554 0.81 L3MBTL1 (0.42) TSHRHSD17B10HPGDL3MBTL1TDP1
SCHEMBL17527769 0.79 L3MBTL1 (0.48) TSHRHSD17B10HPGDL3MBTL1TDP1
SCHEMBL31644868 0.79 ERN1 (0.50) HSD17B10HPGDMAPTLMNAERN1
SCHEMBL28694201 0.78 LMNA (0.42) TSHRHPGDL3MBTL1TDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113913193-B Liquid crystal compound having negative dielectric anisotropy, liquid crystal composition, and liquid crystal display device 烟台显华科技集团股份有限公司 2024-05-17 CN disclosed
CN-114213373-B Synthesis method of dibenzofuran derivative 江苏广域化学有限公司 2023-06-16 CN disclosed
CN-114213373-A Synthesis method of dibenzofuran derivative 江苏广域化学有限公司 2022-03-22 CN disclosed
CN-113913193-A Liquid crystal compound with negative dielectric anisotropy, liquid crystal composition and liquid crystal display device 烟台显华化工科技有限公司 2022-01-11 CN disclosed
US-9540565-B2 Liquid crystal compounds containing dibenzopyran derivatives of naphthenic base and application thereof SHIJIAZHUANG CHENGZHI YONGHUA DISPLAY MATERIALS CO., LTD (CN) 2017-01-10 US disclosed
US-9540565-B2 Liquid crystal compounds containing dibenzopyran derivatives of naphthenic base and application thereof SHIJIAZHUANG CHENGZHI YONGHUA DISPLAY MATERIALS CO., LTD (CN) 2017-01-10 US disclosed
US-20160230092-A1 LIQUID CRYSTAL COMPOUNDS CONTAINING DIBENZOPYRAN DERIVATIVES OF NAPHTHENIC BASE AND APPLICATION THEREOF SHIJIAZHUANG CHENGZHI YONGHUA DISPLAY MATERIALS CO., LTD (CN) 2016-08-11 US disclosed
US-20160230092-A1 LIQUID CRYSTAL COMPOUNDS CONTAINING DIBENZOPYRAN DERIVATIVES OF NAPHTHENIC BASE AND APPLICATION THEREOF SHIJIAZHUANG CHENGZHI YONGHUA DISPLAY MATERIALS CO., LTD (CN) 2016-08-11 US disclosed