SCHEMBL18000000

SCHEMBL18000000

COc1cc(-c2ccc3cc(Br)ccc3c2)ccc1-c1ccc(N(c2ccccc2)c2ccc3ccccc3c2)c2ccccc12

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 2/20 0.35
CYP2A6 P11509 1/20 0.35
CNR2 P34972 1/20 0.35
CDK4 P11802 1/20 0.34
CCNA2 P20248 1/20 0.34
CCND1 P24385 1/20 0.34
CDK2 P24941 1/20 0.34
CCND3 P30281 1/20 0.34
KDR P35968 1/20 0.34
ALOX5 P09917 1/20 0.34
RAC1 P63000 2/20 0.34
NPC1 O15118 1/20 0.33
TSHR P16473 1/20 0.33
RAB9A P51151 1/20 0.33
ESR1 P03372 1/20 0.33
ESR2 Q92731 1/20 0.33
SIRT2 Q8IXJ6 1/20 0.33
ABCB1 P08183 1/20 0.33
ABCC1 P33527 1/20 0.33
ABCG2 Q9UNQ0 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16282199 0.85 MAPT (0.39) CYP2A6KDRRAB9ASMN1; SMN2CYP1A2
SCHEMBL16282214 0.81 TSHR (0.40) CYP2A6KDRTSHRTP53MAPT
SCHEMBL13024054 0.80 CYP2A6 (0.46) CYP2A6CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8051257 0.79 KDM4E (0.35) CYP2A6TSHRTP53RELASMN1; SMN2
SCHEMBL17740540 0.79 ALDH1A1 (0.39) CYP2A6ALOX5NPC1RAB9AABCG2
SCHEMBL17999996 0.78 SLC16A3 (0.42) CYP2A6NPC1TSHRRAB9ASMN1; SMN2
SCHEMBL12888150 0.78 KDM4E (0.34) CYP2A6TSHRTP53RELASMN1; SMN2
SCHEMBL557550 0.77 CYP2A6 (0.45) CYP2A6ALOX5ESR1ESR2SIRT2
SCHEMBL12019896 0.77 RXRA (0.36) ESR1ESR2CYP1A2CYP3A4CYP2D6
SCHEMBL12019775 0.77 RXRA (0.36) ESR1ESR2CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160233428-A1 ORGANIC LIGHT-EMITTING DEVICE SAMSUNG DISPLAY CO., LTD. (KR) 2016-08-11 US disclosed
US-20160233428-A1 ORGANIC LIGHT-EMITTING DEVICE SAMSUNG DISPLAY CO., LTD. (KR) 2016-08-11 US disclosed