Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9597865 | 0.84 | TSHR (0.59) | TRPA1POLBTSHRRECQLALDH1A1 | |
| SCHEMBL893965 | 0.84 | TSHR (0.59) | TRPA1POLBTSHRRECQLALDH1A1 | |
| SCHEMBL1608155 | 0.84 | TSHR (0.59) | TRPA1POLBTSHRRECQLALDH1A1 | |
| SCHEMBL18002366 | 0.83 | DNM1 (0.51) | TRPA1TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL26239812 | 0.81 | ALDH1A1 (0.47) | TRPA1TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL18323943 | 0.81 | DPP7 (0.43) | TRPA1POLBTSHRALDH1A1MEN1 | |
| SCHEMBL3056624 | 0.81 | POLB (0.45) | POLBTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL5425398 | 0.80 | TSHR (0.64) | TRPA1POLBTSHRRECQLALDH1A1 | |
| SCHEMBL12786257 | 0.80 | TSHR (0.64) | TRPA1POLBTSHRRECQLALDH1A1 | |
| SCHEMBL6227253 | 0.79 | POLB (0.54) | POLBTSHRRECQLALDH1A1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3259246-B1 | DERIVATIVES OF SOBETIROME | UNIV OREGON HEALTH & SCIENCE (US) | 2023-03-22 | — | — | EP | disclosed |
| US-20200181103-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2020-06-11 | — | — | US | disclosed |
| US-10392356-B2 | Derivatives of sobetirome | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2019-08-27 | — | — | US | disclosed |
| US-20180057472-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2018-03-01 | — | — | US | disclosed |
| EP-3259246-A1 | DERIVATIVES OF SOBETIROME | Oregon Health & Science University (US) | 2017-12-27 | — | — | EP | disclosed |
| US-9701650-B2 | Derivatives of sobetirome | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2017-07-11 | — | — | US | disclosed |
| WO-2016134292-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2016-08-25 | — | — | WO | disclosed |
| US-20160244418-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2016-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200181103-A1 | DERIVATIVES OF SOBETIROME | SLC18A2, SLC6A2, SLC6A4 | TRPA1 4251/4885POLB 3063/4885TSHR 1896/4885 |
| US-20180057472-A1 | DERIVATIVES OF SOBETIROME | SLC18A2, SLC6A2, SLC6A4 | TRPA1 4251/4885POLB 3063/4885TSHR 1896/4885 |
| US-20160244418-A1 | DERIVATIVES OF SOBETIROME | SLC18A2, SLC6A2, SLC6A4 | TRPA1 4251/4885POLB 3063/4885TSHR 1896/4885 |
| US-10392356-B2 | Derivatives of sobetirome | SLC18A2, SLC6A2, SLC6A4 | TRPA1 4251/4885POLB 3063/4885TSHR 1896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.