Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 11/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.40 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16176863 | 0.88 | PDE5A (0.36) | SLC6A4DHFRPDE5AMAPTMEN1 | |
| SCHEMBL29940550 | 0.88 | PDE5A (0.36) | SLC6A4DHFRPDE5AMAPTMEN1 | |
| SCHEMBL18004160 | 0.83 | PDE5A (0.42) | PDE5A | |
| SCHEMBL18004368 | 0.83 | PDE5A (0.34) | DHFRPDE5AMAPTMEN1KMT2A | |
| SCHEMBL30500634 | 0.81 | DHFR (0.35) | SLC6A4SLC6A2DHFRPDE5AMAPT | |
| SCHEMBL16176916 | 0.81 | DHFR (0.35) | SLC6A4SLC6A2DHFRPDE5AMAPT | |
| SCHEMBL16071766 | 0.79 | ALDH1A1 (0.39) | SLC6A4SLC6A2DHFRPDE5AMAPT | |
| SCHEMBL30262072 | 0.79 | ALDH1A1 (0.39) | SLC6A4SLC6A2DHFRPDE5AMAPT | |
| SCHEMBL18000650 | 0.79 | FGFR4 (0.47) | — | |
| SCHEMBL30485513 | 0.79 | FGFR4 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3259270-A1 | BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS | Incyte Corporation (US) | 2017-12-27 | — | — | EP | disclosed |
| WO-2016134314-A1 | BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS | INCYTE CORPORATION (US) | 2016-08-25 | — | — | WO | disclosed |