Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16176863 | 1.00 | PDE5A (0.36) | PDE5AMAPTKMT2AMEN1HTR2A | |
| SCHEMBL18004149 | 0.88 | SLC6A4 (0.42) | PDE5AMAPTKMT2AMEN1SLC6A4 | |
| SCHEMBL16176631 | 0.87 | SLC6A4 (0.34) | PDE5AMAPTKMT2AMEN1HTR2A | |
| SCHEMBL18004154 | 0.86 | PDE5A (0.38) | PDE5ASLC6A4CYP3A4CYP2C19KDM4E | |
| SCHEMBL18004160 | 0.84 | PDE5A (0.42) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL18004368 | 0.84 | PDE5A (0.34) | PDE5AMAPTKMT2AMEN1CYP3A4 | |
| SCHEMBL28593042 | 0.82 | DHFR (0.36) | KMT2AKDM4ENPSR1ALDH1A1DHFR | |
| SCHEMBL30262072 | 0.80 | ALDH1A1 (0.39) | PDE5AMAPTKMT2AMEN1SLC6A4 | |
| SCHEMBL16071766 | 0.80 | ALDH1A1 (0.39) | PDE5AMAPTKMT2AMEN1SLC6A4 | |
| SCHEMBL18000890 | 0.79 | FGFR4 (0.44) | PDE5AMAPTKMT2AMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113004278-B | Bicyclic heterocycles as FGFR inhibitors | 因赛特控股公司 | 2023-07-21 | — | — | CN | disclosed |
| CN-113024547-B | Bicyclic heterocycles as FGFR4 inhibitors | 因赛特控股公司 | 2023-07-21 | — | — | CN | disclosed |
| WO-2023039828-A1 | FUSED RING COMPOUNDS AS INHIBITORS OF FGFR4 TYROSINE KINASES | NUTSHELL BIOTECH (SHANGHAI) CO., LTD. (CN) | 2023-03-23 | — | — | WO | disclosed |
| CN-115785090-A | Crystalline forms of FGFR inhibitors and methods of making the same | 因赛特公司 | 2023-03-14 | — | — | CN | disclosed |
| CN-111148745-B | Crystalline forms of FGFR inhibitors and methods of making the same | 因赛特公司 | 2022-11-11 | — | — | CN | disclosed |