Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4128931 | 0.85 | RAB9A (0.61) | SMN1; SMN2RAB9AALDH1A1TSHRP2RY1 | |
| SCHEMBL6070400 | 0.85 | HPGD (0.44) | SMN1; SMN2RAB9AALDH1A1HPGDHSD11B1 | |
| SCHEMBL4131021 | 0.81 | P2RY1 (0.66) | SMN1; SMN2RAB9AALDH1A1TSHRP2RY1 | |
| SCHEMBL12617577 | 0.78 | MGLL (0.45) | SMN1; SMN2RAB9AALDH1A1TSHRP2RY1 | |
| SCHEMBL1799232 | 0.78 | MGLL (0.45) | SMN1; SMN2RAB9AALDH1A1TSHRP2RY1 | |
| SCHEMBL5262721 | 0.77 | PTGDR2 (0.69) | P2RY1PTGDR2MEN1KMT2A | |
| SCHEMBL12617633 | 0.77 | PTGDR2 (0.69) | P2RY1PTGDR2MEN1KMT2A | |
| SCHEMBL1800686 | 0.77 | PTGDR2 (0.69) | P2RY1PTGDR2MEN1KMT2A | |
| SCHEMBL5315478 | 0.77 | PTGDR2 (0.69) | P2RY1PTGDR2MEN1KMT2A | |
| SCHEMBL5262719 | 0.77 | PTGDR2 (0.69) | P2RY1PTGDR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951950-B2 | PGD2 receptor antagonists for the treatment of inflammatory diseases | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| EP-1861372-A1 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-12-05 | — | — | EP | disclosed |
| US-20060241109-A1 | PGD2 receptor antagonists for the treatment of inflammatory diseases | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-10-26 | — | — | US | disclosed |
| WO-2006091674-A1 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241109-A1 | PGD2 receptor antagonists for the treatment of inflammatory diseases | PTGER2, PTGDR2, PTGER1 | SMN1; SMN2 4530/4885RAB9A 3908/4885ALDH1A1 2836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.