Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 4/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16618947 | 0.81 | ALDH1A1 (0.44) | ALDH1A1KDM4EIMPDH2ERN1HTR1D | |
| SCHEMBL16727203 | 0.80 | TP53 (0.33) | — | |
| SCHEMBL1093392 | 0.76 | ALDH1A1 (0.54) | ALDH1A1KDM4EIMPDH2ERN1MEN1 | |
| SCHEMBL18014679 | 0.71 | ALDH1A1 (0.59) | ALDH1A1KDM4EIMPDH2ERN1MEN1 | |
| SCHEMBL30995729 | 0.68 | ALDH1A1 (0.70) | ALDH1A1KDM4EIMPDH2MEN1KMT2A | |
| SCHEMBL2275437 | 0.68 | ALDH1A1 (0.70) | ALDH1A1KDM4EIMPDH2MEN1KMT2A | |
| SCHEMBL14033478 | 0.67 | ERN1 (0.52) | ALDH1A1KDM4EERN1MEN1KMT2A | |
| SCHEMBL29953689 | 0.67 | ERN1 (0.52) | ALDH1A1KDM4EERN1MEN1KMT2A | |
| SCHEMBL12450080 | 0.67 | ERN1 (0.52) | ALDH1A1KDM4EERN1MEN1KMT2A | |
| SCHEMBL28062880 | 0.67 | ALDH1A1 (0.46) | ALDH1A1KDM4EIMPDH2ERN1HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160229847-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER (US) | 2016-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229847-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | BACE1, BACE2, PSEN2 | ALDH1A1 1923/4885KDM4E 2364/4885IMPDH2 1323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.