Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 6/20 | 0.45 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | CCR4 | P51679 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18014690 | 0.88 | ALDH1A1 (0.67) | ALDH1A1TDP1L3MBTL1HTR2CCCR4 | |
| SCHEMBL16629847 | 0.83 | ALDH1A1 (0.55) | ALDH1A1TDP1L3MBTL1HTR2CPANK3 | |
| SCHEMBL22792104 | 0.75 | KDM4E (0.57) | ALDH1A1TDP1L3MBTL1HTR2CPANK3 | |
| SCHEMBL18014743 | 0.74 | CCR4 (0.43) | ALDH1A1TDP1L3MBTL1CCR4KDM4E | |
| SCHEMBL13021103 | 0.74 | GFER (0.66) | ALDH1A1TDP1KDM4ECNR1CNR2 | |
| SCHEMBL18014691 | 0.73 | L3MBTL1 (0.63) | ALDH1A1TDP1L3MBTL1HTR2CKDM4E | |
| SCHEMBL18997338 | 0.73 | ALDH1A1 (0.70) | ALDH1A1TDP1CCR4KDM4EHPGD | |
| SCHEMBL10025207 | 0.73 | KDM4E (0.54) | CCR4KDM4ECNR1CNR2HPGD | |
| SCHEMBL18014768 | 0.72 | NPSR1 (0.44) | ALDH1A1TDP1L3MBTL1CNR1CNR2 | |
| SCHEMBL18014794 | 0.72 | ALDH1A1 (0.46) | ALDH1A1TDP1L3MBTL1KDM4ECNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160229847-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER (US) | 2016-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229847-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | BACE1, BACE2, PSEN2 | ALDH1A1 1923/4885TDP1 860/4885L3MBTL1 4677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.