Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 6/20 | 0.48 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18015824 | 0.87 | ALDH1A1 (0.73) | ALDH1A1TDP1L3MBTL1HTR2CKDM4E | |
| SCHEMBL18014797 | 0.83 | ALDH1A1 (0.51) | ALDH1A1TDP1L3MBTL1HTR2CPANK3 | |
| SCHEMBL22792104 | 0.79 | KDM4E (0.57) | ALDH1A1TDP1L3MBTL1HTR2CPANK3 | |
| SCHEMBL6226222 | 0.75 | ALDH1A1 (0.47) | ALDH1A1TDP1L3MBTL1KDM4ENPC1 | |
| SCHEMBL18015816 | 0.74 | L3MBTL1 (0.69) | ALDH1A1TDP1L3MBTL1HTR2CKDM4E | |
| SCHEMBL20255689 | 0.74 | SHMT1 (0.55) | ALDH1A1TDP1L3MBTL1TLR7KDM4E | |
| SCHEMBL10062532 | 0.74 | RAB9A (0.48) | ALDH1A1TDP1L3MBTL1KDM4ENPC1 | |
| SCHEMBL5023376 | 0.73 | LMNA (0.56) | TDP1L3MBTL1TLR7KDM4ENPC1 | |
| SCHEMBL20255498 | 0.72 | SHMT2 (0.70) | ALDH1A1HTR2CPANK3TLR7KDM4E | |
| SCHEMBL18015818 | 0.72 | TDP1 (0.44) | ALDH1A1TDP1L3MBTL1HTR2CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160229847-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER (US) | 2016-08-11 | — | — | US | disclosed |
| WO-2015049616-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER INC. (US) | 2015-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229847-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | BACE1, BACE2, PSEN2 | ALDH1A1 1923/4885TDP1 860/4885L3MBTL1 4677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.