Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10102100 | 0.85 | KDM4E (0.40) | SMN1; SMN2NPC1RAB9AMAOBKDM4E | |
| SCHEMBL23591285 | 0.85 | SNCA (0.40) | SMN1; SMN2NPC1RAB9AMAOBKDM4E | |
| SCHEMBL17244914 | 0.84 | RAB9A (0.46) | SMN1; SMN2NPC1RAB9ATSHRMAOB | |
| SCHEMBL6744336 | 0.83 | TSHR (0.44) | SMN1; SMN2NPC1RAB9ATSHRMAOB | |
| SCHEMBL12279737 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9ATSHRMAOB | |
| SCHEMBL3958112 | 0.81 | LCK (0.55) | SMN1; SMN2TSHRKDM4ELCKFYN | |
| SCHEMBL16181220 | 0.80 | LCK (0.55) | SMN1; SMN2RAB9ATSHRLMNALCK | |
| SCHEMBL12325018 | 0.78 | MAOB (0.46) | SMN1; SMN2TSHRLMNAMAOBKDM4E | |
| SCHEMBL3203530 | 0.77 | SMN1; SMN2 (0.48) | SMN1; SMN2TSHRMAOBKDM4EHTT | |
| SCHEMBL10102096 | 0.77 | LCK (0.40) | SMN1; SMN2RAB9ATSHRLCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11024815-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2021-06-01 | — | — | US | disclosed |
| US-20180026209-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2018-01-25 | — | — | US | disclosed |
| US-20180026209-A1 | Metal Complexes | MERCK PATENT GMBH (DE) | 2018-01-25 | — | — | US | disclosed |
| WO-2016124304-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2016-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11024815-B2 | Metal complexes | EXOC4, EXOC3, TIMCC | SMN1; SMN2 4799/4885NPC1 4039/4885RAB9A 2171/4885 |
| US-20180026209-A1 | Metal Complexes | AP3M1, AP2M1, SOD1 | SMN1; SMN2 4144/4885NPC1 2761/4885RAB9A 1433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.