Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 11/20 | 0.41 |
| ▸ | AKT3 | Q9Y243 | 11/20 | 0.41 |
| ▸ | AKT2 | P31751 | 10/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12193947 | 0.86 | ADRB2 (0.44) | ALDH1A1L3MBTL1POLBMEN1KMT2A | |
| SCHEMBL681411 | 0.85 | MAPT (0.41) | ALDH1A1L3MBTL1AKT3POLBMEN1 | |
| SCHEMBL684403 | 0.83 | BRD4 (0.47) | ALDH1A1L3MBTL1AKT1AKT3AKT2 | |
| SCHEMBL22288404 | 0.83 | POLB (0.55) | ALDH1A1L3MBTL1AKT1AKT3AKT2 | |
| SCHEMBL683279 | 0.83 | BRD4 (0.47) | ALDH1A1L3MBTL1AKT1AKT3AKT2 | |
| SCHEMBL16625002 | 0.83 | POLB (0.55) | ALDH1A1L3MBTL1AKT1AKT3AKT2 | |
| SCHEMBL684107 | 0.83 | BRD4 (0.47) | ALDH1A1L3MBTL1AKT1AKT3AKT2 | |
| SCHEMBL12102359 | 0.83 | CYP2D6 (0.55) | ALDH1A1POLBMEN1KMT2ACNR1 | |
| SCHEMBL12219558 | 0.82 | LMNA (0.40) | MEN1KMT2A | |
| SCHEMBL680733 | 0.82 | FFAR2 (0.41) | L3MBTL1AKT3AKT2POLBFFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160235754-A1 | HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2016-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160235754-A1 | HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | AKT1, AKT2, AKT3 | ALDH1A1 2098/4885L3MBTL1 2443/4885AKT1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.