Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1672474 | 0.75 | POLB (0.50) | POLBMAPTGAAKMT2ACYP1A2 | |
| SCHEMBL12410906 | 0.71 | GAA (0.52) | POLBGAAKMT2ACYP1A2CASP1 | |
| SCHEMBL8349356 | 0.71 | KMT2A (0.54) | POLBMAPTGAAKMT2ASMN1; SMN2 | |
| SCHEMBL9741185 | 0.69 | KMT2A (0.47) | POLBMAPTRAB9AKMT2ACYP1A2 | |
| SCHEMBL12963418 | 0.68 | KMT2A (0.50) | MAPTGAAKMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL6552483 | 0.68 | KMT2A (0.42) | MAPTGAAKMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL12933406 | 0.67 | KMT2A (0.41) | MAPTGAAKMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL22228311 | 0.67 | KMT2A (0.73) | POLBRAB9AGAAKMT2ASMN1; SMN2 | |
| SCHEMBL3708228 | 0.67 | TAAR1 (0.61) | POLBMAPTRAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL5447308 | 0.67 | RAPGEF4 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016129983-A1 | NOVEL N-ACYL-ARYLSULFONAMIDE DERIVATIVES AS AMINOACYL-TRNA SYNTHETASE INHIBITORS | LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) | 2016-08-18 | — | — | WO | disclosed |