Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 7/20 | 0.44 |
| ▸ | MMP2 | P08253 | 6/20 | 0.44 |
| ▸ | MMP8 | P22894 | 6/20 | 0.44 |
| ▸ | MMP9 | P14780 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13245313 | 0.89 | MMP13 (0.47) | MMP13MMP2MMP8MMP9KDM4E | |
| SCHEMBL13245276 | 0.87 | MMP13 (0.47) | MMP13MMP2MMP8MMP9KDM4E | |
| SCHEMBL13245282 | 0.83 | MMP13 (0.44) | MMP13MMP2MMP8MMP9KDM4E | |
| SCHEMBL13984728 | 0.83 | MMP13 (0.44) | MMP13MMP2MMP8MMP9KDM4E | |
| SCHEMBL13244524 | 0.80 | MMP13 (0.44) | MMP13MMP2MMP8MMP9NPC1 | |
| SCHEMBL3018715 | 0.80 | MMP13 (0.44) | MMP13MMP2MMP8MMP9NPC1 | |
| SCHEMBL3014393 | 0.80 | MMP13 (0.44) | MMP13MMP2MMP8MMP9NPC1 | |
| SCHEMBL3018729 | 0.80 | MMP13 (0.44) | MMP13MMP2MMP8MMP9NPC1 | |
| SCHEMBL13244680 | 0.80 | MMP13 (0.44) | MMP13MMP2MMP8MMP9NPC1 | |
| SCHEMBL3014407 | 0.80 | MMP13 (0.44) | MMP13MMP2MMP8MMP9NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170814-B1 | ANTIBACTERIAL AGENTS | ACHAOGEN INC (US) | 2016-08-17 | — | — | EP | disclosed |