SCHEMBL18023933

SCHEMBL18023933

Cc1cccc(NC(=O)Nc2cccc([C@H](C)Nc3cncc(-c4cccnc4)n3)c2)c1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 15/20 0.58
RET P07949 1/20 0.57
PDGFRB P09619 1/20 0.57
KIT P10721 1/20 0.57
SRC P12931 1/20 0.57
PDGFRA P16234 1/20 0.57
FLT1 P17948 1/20 0.57
FLT4 P35916 1/20 0.57
KDR P35968 1/20 0.57
FRK P42685 1/20 0.57
DDR1 Q08345 1/20 0.57
LDHA P00338 1/20 0.54
LDHB P07195 1/20 0.54
GAA P10253 1/20 0.52
IMPDH2 P12268 1/20 0.48
IRAK4 Q9NWZ3 1/20 0.47
PKM P14618 1/20 0.46
KMT2A Q03164 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18023935 0.87 CSF1R (0.59) CSF1RKDRLDHALDHBKMT2A
SCHEMBL20100909 0.86 CSF1R (0.72) CSF1RRETPDGFRBKITSRC
SCHEMBL13339854 0.85 CSF1R (0.77) CSF1RRETPDGFRBKITSRC
SCHEMBL19447218 0.84 LDHA (0.56) CSF1RRETPDGFRBKITSRC
SCHEMBL19447217 0.81 CSF1R (0.59) CSF1RRETPDGFRBKITSRC
SCHEMBL13339849 0.80 CSF1R (0.75) CSF1RRETPDGFRBKITSRC
SCHEMBL18023930 0.79 CSF1R (0.64) CSF1RRETPDGFRBKITSRC
SCHEMBL13340136 0.78 CSF1R (0.71) CSF1RRETPDGFRBKITSRC
SCHEMBL19447262 0.78 CSF1R (0.71) CSF1RRETPDGFRBKITSRC
SCHEMBL13339859 0.78 CSF1R (0.79) CSF1RRETPDGFRBKITSRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3054937-B1 SPRAY DRY FORMULATIONS PULMOKINE INC (US) 2023-07-26 EP disclosed
US-20160235742-A1 SPRAY DRY FORMULATIONS GILEAD SCIENCES, INC. 2016-08-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160235742-A1 SPRAY DRY FORMULATIONS FLT1, KDR, ERBB2 CSF1R 169/4885RET 13/4885PDGFRB 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.