Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GPR183 | P32249 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | YAP1 | P46937 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1798294 | 0.86 | SIGMAR1 (0.52) | SMN1; SMN2GPR183SIGMAR1ALDH1A1KMT2A | |
| SCHEMBL1800968 | 0.85 | CYP3A4 (0.41) | ALDH1A1KMT2AMEN1KDM4EGAA | |
| SCHEMBL3917062 | 0.84 | CHRM5 (0.46) | ALDH1A1KMT2AMEN1LMNAKDM4E | |
| SCHEMBL1803451 | 0.83 | ALDH1A1 (0.44) | ALDH1A1 | |
| SCHEMBL2942516 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2GPR183SIGMAR1ALDH1A1KMT2A | |
| SCHEMBL1798796 | 0.83 | KMT2A (0.37) | SMN1; SMN2ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL1801173 | 0.81 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3920476 | 0.81 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL1801220 | 0.80 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL1798595 | 0.80 | LMNA (0.46) | SMN1; SMN2ALDH1A1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951815-B2 | Substituted 1,4,8-triazaspiro [4,5]decan-2-one compounds | GRUENENTHAL GMBH (DE) | 2011-05-31 | — | — | US | claimed |
| US-7951815-B2 | Substituted 1,4,8-triazaspiro [4,5]decan-2-one compounds | GRUENENTHAL GMBH (DE) | 2011-05-31 | — | — | US | disclosed |