Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 4/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18081013 | 0.80 | MAOA (0.42) | GRIN2BOPRM1CYP46A1ALDH1A1MAOA | |
| SCHEMBL20012538 | 0.78 | OPRM1 (0.40) | GRIN2BOPRM1CYP46A1ALDH1A1OPRL1 | |
| SCHEMBL20008955 | 0.77 | CYP2D6 (0.44) | GRIN2BOPRM1CYP46A1ALDH1A1OPRL1 | |
| SCHEMBL14000290 | 0.76 | CYP46A1 (0.45) | GRIN2BOPRM1KCNH2CYP46A1MAOA | |
| SCHEMBL18038748 | 0.75 | OPRD1 (0.47) | CYP46A1 | |
| SCHEMBL17465635 | 0.73 | OPRM1 (0.47) | GRIN2BCHRM2GRIN2DGRIN3BCHRM1 | |
| SCHEMBL16601016 | 0.72 | MAOA (0.45) | GRIN2BOPRM1CYP46A1MAOAMAOB | |
| SCHEMBL8261420 | 0.72 | OPRM1 (0.56) | GRIN2BCHRM2GRIN2DGRIN3BCHRM1 | |
| SCHEMBL2952979 | 0.71 | OPRD1 (0.51) | CHRM2CHRM1CYP46A1CHRM3SMN1; SMN2 | |
| SCHEMBL28793512 | 0.71 | OPRM1 (0.51) | GRIN2BCHRM2GRIN2DGRIN3BCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3262036-A1 | THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF | Genentech, Inc. (US) | 2018-01-03 | — | — | EP | disclosed |
| WO-2016138114-A1 | THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-09-01 | — | — | WO | disclosed |