Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 7/20 | 0.39 |
| ▸ | PPARA | Q07869 | 6/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | MC5R | P33032 | 1/20 | 0.39 |
| ▸ | MC3R | P41968 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.38 |
| ▸ | PSAT1 | Q9Y617 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18039658 | 1.00 | ALDH1A1 (0.41) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL18039443 | 0.91 | MME (0.44) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL18039441 | 0.91 | MME (0.44) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL18039655 | 0.86 | MC4R (0.43) | ALDH1A1PPARGPPARAMC4RMC5R | |
| SCHEMBL18039657 | 0.86 | MC4R (0.43) | ALDH1A1PPARGPPARAMC4RMC5R | |
| SCHEMBL30901637 | 0.80 | SRR (0.45) | ALDH1A1PPARGPPARAMMP8PPARD | |
| SCHEMBL18039561 | 0.76 | MME (0.43) | ALDH1A1LMNAL3MBTL1MMEMEN1 | |
| SCHEMBL18039558 | 0.76 | MME (0.43) | ALDH1A1LMNAL3MBTL1MMEMEN1 | |
| SCHEMBL18039615 | 0.76 | MME (0.43) | ALDH1A1LMNAL3MBTL1MMEMEN1 | |
| SCHEMBL18039614 | 0.76 | MME (0.43) | ALDH1A1LMNAL3MBTL1MMEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016135751-A1 | NOVEL PROCESS FOR THE PREPARATION OF SACUBITRIL AND ITS INTERMEDIATES | MYLAN LABORATORIES LIMITED (IN) | 2016-09-01 | — | — | WO | disclosed |