Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 5/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
| ▸ | SGK1 | O00141 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1802901 | 0.91 | BRD4 (0.41) | BRD4ALDH1A1LMNAHTR6SLC22A12 | |
| SCHEMBL5609434 | 0.88 | CDK1 (0.39) | BRD4SGK1ALDH1A1LMNAPGR | |
| SCHEMBL5608553 | 0.88 | PKM (0.40) | BRD4SGK1ALDH1A1LMNAHTR6 | |
| SCHEMBL1806802 | 0.85 | LMNA (0.39) | BRD4ALDH1A1LMNAHTR6MEN1 | |
| SCHEMBL3906659 | 0.85 | PTGES2 (0.47) | PTGES2BRD4GHSRSGK1ALDH1A1 | |
| SCHEMBL1819904 | 0.85 | BRD4 (0.52) | BRD4LMNAPGRHTR6 | |
| SCHEMBL1804773 | 0.84 | MEN1 (0.46) | BRD4ALDH1A1LMNAHTR6MEN1 | |
| SCHEMBL5609197 | 0.81 | PFKFB3 (0.40) | ALDH1A1LMNAHTR6MEN1THRB | |
| SCHEMBL1809645 | 0.77 | PTGES2 (0.46) | PTGES2BRD4GHSRSGK1ALDH1A1 | |
| SCHEMBL3905782 | 0.76 | GSPT1 (0.41) | PTGES2BRD4ALDH1A1LMNASLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4682207-B2 | — | — | 2011-05-11 | — | — | JP | claimed |
| EP-1797042-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-20 | — | — | EP | claimed |
| WO-2006034804-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-06 | — | — | WO | claimed |