Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5608553 | 0.94 | PKM (0.40) | BRD4ALDH1A1MAPTMEN1POLB | |
| SCHEMBL1806802 | 0.93 | LMNA (0.39) | CDK1CCNB1CCNA2CDK2CDK7 | |
| SCHEMBL1804100 | 0.88 | PTGES2 (0.44) | BRD4ALDH1A1PGRMEN1KMT2A | |
| SCHEMBL1804773 | 0.86 | MEN1 (0.46) | BRD4ALDH1A1MAPTMEN1POLB | |
| SCHEMBL1802901 | 0.86 | BRD4 (0.41) | BRD4ALDH1A1MEN1KMT2AHTR6 | |
| SCHEMBL3911569 | 0.84 | CDK1 (0.41) | CDK1CCNB1CCNA2CCND1CDK2 | |
| SCHEMBL1819904 | 0.83 | BRD4 (0.52) | BRD4PGRMAPTHTR6PKM | |
| SCHEMBL5609197 | 0.83 | PFKFB3 (0.40) | ALDH1A1MAPTMEN1KMT2AGAA | |
| SCHEMBL3906967 | 0.78 | PKM (0.40) | CDK1CCNB1CCNA2CCND1CDK2 | |
| SCHEMBL3913835 | 0.78 | LMNA (0.39) | CDK1CCNB1CCNA2CDK2CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006034804-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-06 | — | — | WO | disclosed |