Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.68 |
| ▸ | RXRB | P28702 | 1/20 | 0.68 |
| ▸ | GPR3 | P46089 | 1/20 | 0.61 |
| ▸ | KIF11 | P52732 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL883709 | 1.00 | RXRA (0.68) | RXRARXRBGPR3KIF11MAOB | |
| SCHEMBL17250115 | 0.96 | RXRA (0.64) | RXRARXRBGPR3KIF11MAOB | |
| SCHEMBL19986206 | 0.95 | RXRA (0.62) | RXRARXRBGPR3KIF11MAOB | |
| SCHEMBL22192128 | 0.95 | RXRA (0.62) | RXRARXRBGPR3KIF11MAOB | |
| SCHEMBL10052455 | 0.95 | RXRA (0.62) | RXRARXRBGPR3KIF11MAOB | |
| SCHEMBL20842551 | 0.95 | RXRA (0.62) | RXRARXRBGPR3KIF11MAOB | |
| SCHEMBL16373476 | 0.94 | GPR3 (0.70) | RXRARXRBGPR3KIF11MAOB | |
| SCHEMBL10052702 | 0.94 | RXRA (0.59) | RXRARXRBGPR3KIF11MAOB | |
| SCHEMBL12943203 | 0.92 | RXRA (0.63) | RXRARXRBGPR3KIF11MAOB | |
| SCHEMBL12943204 | 0.92 | RXRA (0.63) | RXRARXRBGPR3KIF11MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11518756-B2 | Arylation method | UMICORE AG & CO. KG (DE) | 2022-12-06 | — | — | US | claimed |
| EP-3383861-B1 | BUCHWALD-HARTWIG ARYLATION METHOD FOR THE PREPARATION OF TERTIARY AMINES | UMICORE AG & CO KG (DE) | 2021-03-17 | — | — | EP | claimed |
| US-20200031803-A1 | ARYLATION METHOD | UMICORE AG & CO. KG (DE) | 2020-01-30 | — | — | US | claimed |
| EP-3060548-B1 | MONO ARYLATION OF AROMATIC AMINES | UMICORE AG & CO KG (DE) | 2018-10-10 | — | — | EP | claimed |
| EP-3383861-A2 | ARYLATION METHOD | Umicore AG & Co. KG (DE) | 2018-10-10 | — | — | EP | claimed |
| US-20160257650-A1 | MONOARYLATION OF AROMATIC AMINES | UMICORE AG & CO. KG (DE) | 2016-09-08 | — | — | US | claimed |
| US-11518756-B2 | Arylation method | UMICORE AG & CO. KG (DE) | 2022-12-06 | — | — | US | disclosed |
| US-20200031803-A1 | ARYLATION METHOD | UMICORE AG & CO. KG (DE) | 2020-01-30 | — | — | US | disclosed |
| EP-3383861-A2 | ARYLATION METHOD | Umicore AG & Co. KG (DE) | 2018-10-10 | — | — | EP | disclosed |
| US-20160257650-A1 | MONOARYLATION OF AROMATIC AMINES | UMICORE AG & CO. KG (DE) | 2016-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11518756-B2 | Arylation method | AHR, ARNT, CYP2B6 | RXRA 331/4885RXRB 178/4885GPR3 865/4885 |
| US-20160257650-A1 | MONOARYLATION OF AROMATIC AMINES | AHR, TYR, CYP1A2 | RXRA 1846/4885RXRB 1203/4885GPR3 595/4885 |
| US-20200031803-A1 | ARYLATION METHOD | AHR, ARNT, CYP2B6 | RXRA 331/4885RXRB 178/4885GPR3 865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.