Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | RHOA | P61586 | 3/20 | 0.47 |
| ▸ | RHOC | P08134 | 1/20 | 0.47 |
| ▸ | F13A1 | P00488 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | TGM1 | P22735 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30507625 | 1.00 | RAB9A (0.55) | RAB9ANPC1ABL1RIN1ALDH1A1 | |
| SCHEMBL18045231 | 1.00 | RAB9A (0.55) | RAB9ANPC1ABL1RIN1ALDH1A1 | |
| SCHEMBL18045249 | 0.94 | PTPN2 (0.61) | RAB9ANPC1ABL1RIN1ALDH1A1 | |
| SCHEMBL16151174 | 0.94 | PTPN2 (0.61) | RAB9ANPC1ABL1RIN1ALDH1A1 | |
| SCHEMBL21670584 | 0.89 | RAB9A (0.54) | RAB9ANPC1ABL1RIN1ALDH1A1 | |
| SCHEMBL28578815 | 0.89 | RAB9A (0.54) | RAB9ANPC1ABL1RIN1ALDH1A1 | |
| SCHEMBL21670403 | 0.87 | RAB9A (0.54) | RAB9ANPC1ABL1RIN1ALDH1A1 | |
| SCHEMBL193295 | 0.86 | RAB9A (0.65) | RAB9ANPC1ABL1RIN1PTPN2 | |
| SCHEMBL193294 | 0.86 | RAB9A (0.65) | RAB9ANPC1ABL1RIN1PTPN2 | |
| SCHEMBL28589348 | 0.85 | RAB9A (0.61) | RAB9ANPC1ALDH1A1HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112679489-B | N-sulfonyl heterocyclic derivative and pharmaceutical use thereof | 重庆医科大学 | 2023-07-25 | — | — | CN | disclosed |
| CN-112679489-A | N-sulfonyl heterocyclic derivatives and pharmaceutical use thereof | 重庆医科大学 | 2021-04-20 | — | — | CN | disclosed |
| US-10377709-B2 | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | JANSSEN SCIENCES IRELAND UC (IE) | 2019-08-13 | — | — | US | disclosed |
| US-20190002406-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN SCIENCES IRELAND UC (IE) | 2019-01-03 | — | — | US | disclosed |
| US-10071961-B2 | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | JANSSEN SCIENCES IRELAND UC (IE) | 2018-09-11 | — | — | US | disclosed |
| US-20180065929-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN SCIENCES IRELAND UC (IE) | 2018-03-08 | — | — | US | disclosed |
| EP-3060547-B1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN SCIENCES IRELAND UC (IE) | 2017-10-11 | — | — | EP | disclosed |
| US-20170158634-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN SCIENCES IRELAND UC (IE) | 2017-06-08 | — | — | US | disclosed |
| US-9567299-B2 | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | JANSSEN SCIENCES IRELAND UC (IE) | 2017-02-14 | — | — | US | disclosed |
| US-20160264522-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN INFECTIOUS DISEASES BVBA (BE) | 2016-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190002406-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | HCCS, XDH, NR1H4 | RAB9A 3354/4885NPC1 1185/4885ABL1 2190/4885 |
| US-10071961-B2 | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | HCCS, NR1H4, GLS2 | RAB9A 3418/4885NPC1 1066/4885ABL1 2104/4885 |
| US-20180065929-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | HCCS, NR1H4, GLS2 | RAB9A 3418/4885NPC1 1066/4885ABL1 2104/4885 |
| US-10377709-B2 | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | HCCS, XDH, NR1H4 | RAB9A 3354/4885NPC1 1185/4885ABL1 2190/4885 |
| US-20160264522-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | HCCS, XDH, NR1H4 | RAB9A 3354/4885NPC1 1185/4885ABL1 2190/4885 |
| US-20170158634-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | HCCS, XDH, NR1H4 | RAB9A 3354/4885NPC1 1185/4885ABL1 2190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.