Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18070760 | 1.00 | PARP1 (0.41) | PARP1GBA1SIGMAR1GSK3AGSK3B | |
| SCHEMBL19990743 | 0.78 | MAPT (0.42) | PARP1GSK3AGSK3BALDH1A1L3MBTL1 | |
| SCHEMBL10455603 | 0.77 | L3MBTL1 (0.44) | GBA1SIGMAR1HTR1AALDH1A1GAA | |
| SCHEMBL5937728 | 0.77 | L3MBTL1 (0.44) | GBA1SIGMAR1HTR1AALDH1A1GAA | |
| SCHEMBL5937718 | 0.77 | L3MBTL1 (0.44) | GBA1SIGMAR1HTR1AALDH1A1GAA | |
| SCHEMBL14063972 | 0.71 | HDAC1 (0.47) | SIGMAR1GAA | |
| SCHEMBL652125 | 0.71 | HTR1A (0.47) | GBA1SIGMAR1HTR1AHTR2AHTR2C | |
| SCHEMBL10078725 | 0.71 | HTR1A (0.47) | GBA1SIGMAR1HTR1AHTR2AHTR2C | |
| SCHEMBL22605206 | 0.71 | HTR1A (0.47) | GBA1SIGMAR1HTR1AHTR2AHTR2C | |
| SCHEMBL652126 | 0.71 | HTR1A (0.47) | GBA1SIGMAR1HTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3268366-A1 | (INDAZOL-4-YL)HEXAHYDROPYRROLOPYRROLONES AND METHOD OF USE | AbbVie Inc. (US) | 2018-01-17 | — | — | EP | disclosed |
| US-9682985-B2 | (Indazol-4-yl) hexahydropyrrolopyrrolones and methods of use | ABBVIE INC. (US) | 2017-06-20 | — | — | US | disclosed |
| WO-2016149169-A1 | (INDAZOL-4-YL)HEXAHYDROPYRROLOPYRROLONES AND METHOD OF USE | ABBVIE INC. (US) | 2016-09-22 | — | — | WO | disclosed |
| US-20160264582-A1 | (Indazol-4-YL) Hexahydropyrrolopyrrolones and Methods of Use | ABBVIE INC. (US) | 2016-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160264582-A1 | (Indazol-4-YL) Hexahydropyrrolopyrrolones and Methods of Use | CACNA1D, CACNA1S, KCNJ11 | PARP1 3400/4885GBA1 210/4885SIGMAR1 2061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.