Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 2/20 | 0.41 |
| ▸ | FNTB | P49356 | 2/20 | 0.41 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1357324 | 0.77 | HDAC1 (0.43) | HDAC1HDAC8HDAC6SIGMAR1OPRM1 | |
| SCHEMBL5937728 | 0.75 | L3MBTL1 (0.44) | SIGMAR1GAA | |
| SCHEMBL10455603 | 0.75 | L3MBTL1 (0.44) | SIGMAR1GAA | |
| SCHEMBL5937718 | 0.75 | L3MBTL1 (0.44) | SIGMAR1GAA | |
| SCHEMBL25524985 | 0.75 | SIGMAR1 (0.55) | HDAC1HDAC8HDAC6SIGMAR1OPRM1 | |
| Hydrochloric Acid SCHEMBL7927508 | 0.74 | HDAC1 (0.48) | HDAC1HDAC8HDAC6MCHR1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7937361 | 0.74 | HDAC1 (0.48) | HDAC1HDAC8HDAC6MCHR1SIGMAR1 | |
| SCHEMBL14177604 | 0.74 | HSD11B1 (0.55) | HDAC1HDAC8HDAC6SIGMAR1OPRM1 | |
| Hydrochloric Acid SCHEMBL7927437 | 0.74 | HDAC1 (0.48) | HDAC1HDAC8HDAC6MCHR1SIGMAR1 | |
| SCHEMBL17144454 | 0.72 | HDAC1 (0.50) | HDAC1HDAC8HDAC6SIGMAR1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7419975-B2 | Organic compounds | NOVARTIS AG (CH) | 2008-09-02 | — | — | US | disclosed |
| US-7419975-B2 | Organic compounds | NOVARTIS AG (CH) | 2008-09-02 | — | — | US | disclosed |