SCHEMBL18050299

SCHEMBL18050299

CCc1ccc(C(=O)OC(=C(OC(=O)c2ccc(CC)cc2)c2ccccc2Cl)c2ccccc2Cl)cc1

nearest known ligand 0.54

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.44
▸ TP53 P04637 1/20 0.44
▸ KMT2A Q03164 1/20 0.44
▸ RAB9A P51151 4/20 0.44
▸ NPC1 O15118 3/20 0.44
▸ ALDH1A1 P00352 3/20 0.43
▸ CES2 O00748 2/20 0.42
▸ CES1 P23141 2/20 0.42
▸ HPGD P15428 2/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ ADRB2 P07550 1/20 0.40
▸ ADRB1 P08588 1/20 0.40
▸ ADRB3 P13945 1/20 0.40
▸ PLK1 P53350 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18050297 1.00 MAPT (0.44) MAPTTP53KMT2ARAB9ANPC1
SCHEMBL19875698 0.90 NPC1 (0.46) MAPTTP53KMT2ARAB9ANPC1
SCHEMBL19875697 0.90 NPC1 (0.46) MAPTTP53KMT2ARAB9ANPC1
SCHEMBL18050362 0.88 TRPV1 (0.46) HPGDPLK1
SCHEMBL18050363 0.88 TRPV1 (0.46) HPGDPLK1
SCHEMBL18050358 0.84 RAB9A (0.46) KMT2ARAB9ANPC1ALDH1A1CES2
SCHEMBL18050360 0.84 RAB9A (0.46) KMT2ARAB9ANPC1ALDH1A1CES2
SCHEMBL19875700 0.84 RAB9A (0.55) KMT2ARAB9ANPC1ALDH1A1CES2
SCHEMBL19875699 0.84 RAB9A (0.55) KMT2ARAB9ANPC1ALDH1A1CES2
SCHEMBL18050354 0.84 ALDH1A1 (0.53) TP53KMT2ARAB9ANPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3268398-B1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA SRL (IT) 2019-05-15 — — EP disclosed
US-10246532-B2 Catalyst components for the polymerization of olefins BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2019-04-02 — — US disclosed
US-20180051106-A1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2018-02-22 — — US disclosed
EP-3268398-A1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS Basell Poliolefine Italia S.r.l. (IT) 2018-01-17 — — EP disclosed
WO-2016142377-A1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2016-09-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180051106-A1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS C1S, CCNT1, COG1 MAPT 3879/4885TP53 2466/4885KMT2A 1960/4885
US-10246532-B2 Catalyst components for the polymerization of olefins C1S, CCNT1, COG1 MAPT 3879/4885TP53 2466/4885KMT2A 1960/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback