Sugi Predict

Sugi Predict / Targets / COG1

COG1

Conserved oligomeric Golgi complex subunit 1 · Q8WTW3 · COG1 on Sugi Atlas →

0 patent compounds predicted against COG1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to COG1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Hydroxychloroquine Sulfate Alleviates Persistent Proteinuria in IgA Nephropathy PHASE4UNKNOWN
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD PHASE3COMPLETED
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) PHASE1/PHASE2NOT_YET_RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
A Phase 1/2 Study of Intravenous Gene Transfer With an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 Gangliosidosis PHASE1/PHASE2RECRUITING
Reverse Transcriptase Inhibitors in AGS PHASE2COMPLETED
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy PHASE2COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism EARLY_PHASE1UNKNOWN
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Immunological Profile and Clinical Characteristics of Children Diagnosed With Chronic Granulomatous Disease nanUNKNOWN
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM) nanCOMPLETED
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing nanCOMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) nanCOMPLETED
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Quantification of GADD34 Expression in RA nanCOMPLETED
Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy nanCOMPLETED
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia nanUNKNOWN
Use of miRNAs in Growth Hormone Deficiency (GHD) nanUNKNOWN
GNAO1 Natural History Study nanUNKNOWN
Genetic Characterization of Parkinson's Disease nanCOMPLETED
NGLY1 Natural History nanCOMPLETED
Clinical Importance of Carrier Status of Recessive Gene Mutations in Myopathy (CICS) nanUNKNOWN
Genetic Studies of Lysosomal Storage Disorders nanENROLLING_BY_INVITATION
Pediatric Evaluation and Registry for Liver Cholestasis in Canada nanRECRUITING
Protein Synthesis in the Brain of Patients With Fragile X Syndrome nanCOMPLETED
Molecular Genetic Study of Schizophrenia: Parent-Offspring Trios nanCOMPLETED
McArdle Disease Treatment by Ketogenic Diet nanCOMPLETED
Genetic Analysis of Gray Platelet Syndrome nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a COG1 binder may also engage these)

ProteinNameSimilarity
Q9Z160 — 1.000 Q9Z160 →
Q9FFF3 — 0.987 Q9FFF3 →
Q5U1Z0 — 0.987 Q5U1Z0 →
COG7 Conserved oligomeric Golgi complex subunit 7 0.987 landscape →
Q8BMG7 — 0.987 Q8BMG7 →
O88480 — 0.986 O88480 →
O54692 — 0.986 O54692 →
Q8CEC0 — 0.986 Q8CEC0 →
Q9JJA2 — 0.986 Q9JJA2 →
P0DXK2 — 0.986 P0DXK2 →
Q9H2M9 — 0.985 Q9H2M9 →
Q9Z136 — 0.985 Q9Z136 →
Q9C0B7 — 0.985 Q9C0B7 →
COG2 Conserved oligomeric Golgi complex subunit 2 0.985 landscape →
Q6NUQ1 — 0.985 Q6NUQ1 →
A4IF89 — 0.984 A4IF89 →
A2CEI4 — 0.984 A2CEI4 →
Q6PGF7 — 0.984 Q6PGF7 →
MED16 Mediator of RNA polymerase II transcription subunit 16 0.984 landscape →
Q80U93 — 0.984 Q80U93 →
Q566H4 — 0.984 Q566H4 →
Q5F479 — 0.984 Q5F479 →
E7FCN8 — 0.984 E7FCN8 →
Q99K74 — 0.984 Q99K74 →
B0I564 — 0.984 B0I564 →
Q8IYI6 — 0.984 Q8IYI6 →
COG5 Conserved oligomeric Golgi complex subunit 5 0.983 landscape →
O15259 — 0.983 O15259 →
Q5T011 — 0.983 Q5T011 →
Q8N5R6 — 0.983 Q8N5R6 →