Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.39 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3025283 | 1.00 | HTR2A (0.47) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL18052179 | 1.00 | HTR2A (0.47) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL4926513 | 0.87 | SLC6A2 (0.40) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL11549936 | 0.86 | PRMT5 (0.41) | PRMT5WDR77SLC12A2SLC12A5ALDH1A1 | |
| SCHEMBL9842215 | 0.83 | PRMT5 (0.54) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL19285370 | 0.83 | SLC12A2 (0.47) | PRMT5WDR77SLC12A2SLC12A5ALDH1A1 | |
| SCHEMBL283511 | 0.83 | SLC12A2 (0.47) | PRMT5WDR77SLC12A2SLC12A5ALDH1A1 | |
| SCHEMBL19285120 | 0.83 | SLC12A2 (0.47) | PRMT5WDR77SLC12A2SLC12A5ALDH1A1 | |
| SCHEMBL30567848 | 0.81 | CRBN (0.43) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL439062 | 0.79 | PRMT5 (0.54) | PRMT5WDR77SLC12A2SLC12A5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197874-B1 | PYRAZIN-2-YL-PYRIDIN-2-YL-AMINE AND PYRAZIN-2-YL-PYRIMIDIN-4-YL-AMINE COMPOUNDS AND THEIR USE | CANCER REC TECH LTD (GB) | 2016-08-31 | — | — | EP | disclosed |