Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.39 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18052240 | 1.00 | HTR2A (0.47) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL18052179 | 1.00 | HTR2A (0.47) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL4926513 | 0.87 | SLC6A2 (0.40) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL11549936 | 0.86 | PRMT5 (0.41) | PRMT5WDR77SLC12A2SLC12A5ALDH1A1 | |
| SCHEMBL9842215 | 0.83 | PRMT5 (0.54) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL19285370 | 0.83 | SLC12A2 (0.47) | PRMT5WDR77SLC12A2SLC12A5ALDH1A1 | |
| SCHEMBL283511 | 0.83 | SLC12A2 (0.47) | PRMT5WDR77SLC12A2SLC12A5ALDH1A1 | |
| SCHEMBL19285120 | 0.83 | SLC12A2 (0.47) | PRMT5WDR77SLC12A2SLC12A5ALDH1A1 | |
| SCHEMBL30567848 | 0.81 | CRBN (0.43) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL439062 | 0.79 | PRMT5 (0.54) | PRMT5WDR77SLC12A2SLC12A5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100210640-A1 | BENZAMIDE DERIVATIVES, THEIR PREPARATION AND USES IN MEDICINE THEREOF | JIANGSU HENGRUI MEDICINE CO. LTD. (CN) | 2010-08-19 | — | — | US | disclosed |
| EP-2189451-A1 | BENZAMIDE DERIVATIVES, THEIR PREPARATION AND USES IN MEDICINE THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2010-05-26 | — | — | EP | disclosed |
| EP-1050534-B1 | 2,3-methano-amino acid derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2001-12-05 | — | — | EP | disclosed |
| US-6288077-B1 | 2-AZABICYCLO(3.1.0)HEXANE-1,2-DICARBOXYLIC AMIDE OR 2-AZABICYCLO(4.1.0)HEPTANE-1,2-DICARBOXYLIC AMIDE DERIVATIVE; TRYPSIN-LIKE SERINE PROTEASE INHIBITOR; ANTICOAGULANTS | ADIR ET COMPAGNIE (FR) | 2001-09-11 | — | — | US | disclosed |
| EP-1050534-A1 | 2,3-methano-amino acid derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-11-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210640-A1 | BENZAMIDE DERIVATIVES, THEIR PREPARATION AND USES IN MEDICINE THEREOF | HTR4, HTR5A, TPH1 | HTR2A 11/4885SLC6A4 22/4885SLC6A2 417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.