Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 5/20 | 0.33 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.33 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CCR1 | P32246 | 3/20 | 0.32 |
| ▸ | ACLY | P53396 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.31 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.31 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3107673 | 0.93 | MRGPRX4 (0.36) | TACR1P2RX1TMPRSS4LMNAHPGD | |
| SCHEMBL29039019 | 0.92 | TACR1 (0.33) | TACR1P2RX1TMPRSS4LMNAHPGD | |
| SCHEMBL3099384 | 0.91 | TACR1 (0.32) | TACR1P2RX1TMPRSS4LMNAHPGD | |
| SCHEMBL3104661 | 0.90 | FAP (0.35) | TACR1P2RX1TMPRSS4LMNAHPGD | |
| Esafoxolaner SCHEMBL18054742 | 0.90 | PTGES (0.33) | TACR1P2RX1TMPRSS4LMNAHPGD | |
| Afoxolaner SCHEMBL18054743 | 0.90 | PTGES (0.33) | TACR1P2RX1TMPRSS4LMNAHPGD | |
| Afoxolaner SCHEMBL29367347 | 0.90 | PTGES (0.33) | TACR1P2RX1TMPRSS4LMNAHPGD | |
| Afoxolaner SCHEMBL119580 | 0.90 | PTGES (0.33) | TACR1P2RX1TMPRSS4LMNAHPGD | |
| Esafoxolaner SCHEMBL29413811 | 0.90 | PTGES (0.33) | TACR1P2RX1TMPRSS4LMNAHPGD | |
| Afoxolaner SCHEMBL29358921 | 0.90 | PTGES (0.33) | TACR1P2RX1TMPRSS4LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016138339-A1 | LONG-ACTING INJECTABLE FORMULATIONS COMPRISING AN ISOXAZOLINE ACTIVE AGENT, METHODS AND USES THEREOF | MERIAL, INC. (US) | 2016-09-01 | — | — | WO | disclosed |