Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | GAA | P10253 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 6/20 | 0.34 |
| ▸ | HPGD | P15428 | 5/20 | 0.34 |
| ▸ | GLA | P06280 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18057397 | 0.86 | KDM4E (0.42) | ALDH1A1KDM4EGAAGLAATM | |
| SCHEMBL18057399 | 0.82 | KDM4E (0.38) | ALDH1A1KDM4EGAANPC1TP53 | |
| SCHEMBL18057405 | 0.81 | ALDH1A1 (0.51) | ALDH1A1KDM4EGAASMN1; SMN2HPGD | |
| SCHEMBL18057403 | 0.81 | ALDH1A1 (0.45) | ALDH1A1KDM4EGAANPC1RAB9A | |
| SCHEMBL18057401 | 0.80 | POLR1A (0.38) | ALDH1A1KDM4EGAAHPGDGLA | |
| SCHEMBL18057406 | 0.74 | ALDH1A1 (0.36) | ALDH1A1KDM4EGAANPC1TP53 | |
| SCHEMBL23160995 | 0.72 | KDM4E (0.41) | ALDH1A1KDM4EGAAGLAATM | |
| SCHEMBL20078424 | 0.70 | MKNK1 (0.43) | ALDH1A1KDM4EGAAGLAATM | |
| SCHEMBL18057396 | 0.69 | HTR3A (0.48) | ALDH1A1KDM4EKMT2A | |
| SCHEMBL18213593 | 0.69 | ALDH1A1 (0.41) | ALDH1A1KDM4EGAASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9758518-B2 | Compositions, uses and methods for making them | Pimera, Inc. (US) | 2017-09-12 | — | — | US | disclosed |
| US-9512123-B2 | Compositions, uses and methods for making them | Pimera, Inc. (US) | 2016-12-06 | — | — | US | disclosed |
| US-20160326176-A1 | Novel Compositions, Uses and Methods for Making Them | PIMERA, INC | 2016-11-10 | — | — | US | disclosed |
| US-20160257678-A1 | NOVEL COMPOSITIONS, USES AND METHODS FOR MAKING THEM | UNITED STATES GOVERNMENT | 2016-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160326176-A1 | Novel Compositions, Uses and Methods for Making Them | BAX, CASP3, BCL2 | ALDH1A1 3544/4885KDM4E 2839/4885GAA 1840/4885 |
| US-20160257678-A1 | NOVEL COMPOSITIONS, USES AND METHODS FOR MAKING THEM | BAX, CASP3, BCL2 | ALDH1A1 3544/4885KDM4E 2839/4885GAA 1840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.