Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 4/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 7/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1803650 | 0.79 | MEN1 (0.37) | DRD1ERN1P2RX7 | |
| SCHEMBL1807207 | 0.79 | ERN1 (0.34) | ERN1 | |
| SCHEMBL1810207 | 0.77 | DRD1 (0.36) | DRD1PDK2HTR1ASLC6A2SLC6A4 | |
| SCHEMBL1808007 | 0.76 | KDM4E (0.34) | NAAA | |
| SCHEMBL1809756 | 0.74 | PDE4D (0.46) | DRD1 | |
| SCHEMBL1807044 | 0.73 | CYP1A2 (0.36) | ERN1 | |
| SCHEMBL1806019 | 0.73 | TRPV1 (0.36) | SLC6A2SLC6A4ERN1SLC6A3 | |
| SCHEMBL1807099 | 0.72 | ALDH1A1 (0.38) | — | |
| SCHEMBL15354765 | 0.70 | PDK2 (0.46) | PDK2HTR1ASLC6A2SLC6A4PDK4 | |
| SCHEMBL32685167 | 0.70 | PDK2 (0.46) | PDK2HTR1ASLC6A2SLC6A4PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501703-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011060035-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |