Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 7/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 4/20 | 0.32 |
| ▸ | SSTR1 | P30872 | 3/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1805952 | 0.77 | DRD1 (0.39) | DRD1P2RX7PDK2HTR1ASLC6A2 | |
| SCHEMBL1809756 | 0.76 | PDE4D (0.46) | DRD1 | |
| SCHEMBL1806341 | 0.74 | TRPV1 (0.37) | P2RX7SLC6A4 | |
| SCHEMBL15354765 | 0.67 | PDK2 (0.46) | PDK2HTR1ASLC6A2SLC6A4PDK4 | |
| SCHEMBL32685167 | 0.67 | PDK2 (0.46) | PDK2HTR1ASLC6A2SLC6A4PDK4 | |
| SCHEMBL17682007 | 0.67 | IDO1 (0.37) | P2RX7OPRL1 | |
| SCHEMBL30852252 | 0.66 | ALDH1A1 (0.52) | P2RX7PDK2HTR1ASLC6A2SLC6A4 | |
| SCHEMBL21942819 | 0.66 | ALDH1A1 (0.52) | P2RX7PDK2HTR1ASLC6A2SLC6A4 | |
| SCHEMBL1808403 | 0.61 | OPRL1 (0.39) | PDK2SSTR4SSTR1OPRL1 | |
| SCHEMBL27956065 | 0.61 | HTR1A (0.41) | PDK2HTR1ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501703-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011060035-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |