Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | AGER | Q15109 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HAO2 | Q9NYQ3 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1806327 | 0.85 | KDM4E (0.44) | KDM4EMAPTALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL1803979 | 0.73 | TDP2 (0.43) | KDM4ECYP3A4NPSR1 | |
| SCHEMBL1807976 | 0.73 | MAPT (0.43) | KDM4EMAPTALDH1A1ALOX15NPSR1 | |
| SCHEMBL1807207 | 0.69 | ERN1 (0.34) | METAP2ERN1TRPV1 | |
| SCHEMBL1803650 | 0.69 | MEN1 (0.37) | METAP2KDM4ETDP1ALDH1A1ERN1 | |
| SCHEMBL29564333 | 0.69 | KDM4E (0.61) | KDM4ETDP1MYCMAPTALDH1A1 | |
| SCHEMBL130171 | 0.69 | KDM4E (0.61) | KDM4ETDP1MYCMAPTALDH1A1 | |
| SCHEMBL4491755 | 0.69 | TRPV1 (0.36) | METAP2KDM4ETDP1MAPTALDH1A1 | |
| SCHEMBL19207072 | 0.68 | NTRK1 (0.41) | METAP2KDM4ETDP1MYCMAPT | |
| SCHEMBL28335924 | 0.68 | KDM4E (0.41) | METAP2KDM4ETDP1MYCMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501703-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011060035-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |