Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1806327 | 0.89 | KDM4E (0.44) | TDP2KDM4EPOLBBRD4SMN1; SMN2 | |
| SCHEMBL1807976 | 0.87 | MAPT (0.43) | TDP2KDM4EPOLBBRD4NPSR1 | |
| SCHEMBL1806148 | 0.86 | KDM4E (0.46) | KDM4EPOLBMEN1KMT2ANPSR1 | |
| SCHEMBL1809016 | 0.83 | KDM4E (0.48) | TDP2KDM4EPOLBMEN1KMT2A | |
| SCHEMBL1806318 | 0.79 | PDE4D (0.50) | TDP2KDM4EPOLBBRD4KMT2A | |
| SCHEMBL1807207 | 0.78 | ERN1 (0.34) | — | |
| SCHEMBL1806943 | 0.76 | TDP2 (0.43) | TDP2POLBBRD4KMT2AJAK2 | |
| SCHEMBL1807759 | 0.76 | TDP2 (0.42) | TDP2KDM4EPOLBBRD4KMT2A | |
| SCHEMBL1803609 | 0.74 | PRKCQ (0.32) | CYP3A4 | |
| SCHEMBL1806255 | 0.73 | METAP2 (0.38) | KDM4ENPSR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501703-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011060035-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |