Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1806327 | 0.89 | KDM4E (0.44) | MAPTALDH1A1KDM4EPOLBBRD4 | |
| SCHEMBL1803979 | 0.87 | TDP2 (0.43) | LMNAKDM4EPOLBBRD4TDP2 | |
| SCHEMBL1803650 | 0.78 | MEN1 (0.37) | ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL10919890 | 0.75 | TDP2 (0.43) | MAPTALDH1A1KDM4EPOLBBRD4 | |
| SCHEMBL14471201 | 0.75 | SMN1; SMN2 (0.49) | MAPTALDH1A1LMNAGAAKDM4E | |
| SCHEMBL13238931 | 0.75 | NUDT1 (0.50) | MAPTALDH1A1BRD4HTTMAPK1 | |
| SCHEMBL1806148 | 0.74 | KDM4E (0.46) | MAPTALDH1A1LMNAGAAKDM4E | |
| SCHEMBL1809016 | 0.74 | KDM4E (0.48) | MAPTALDH1A1LMNAKDM4EPOLB | |
| SCHEMBL1806255 | 0.73 | METAP2 (0.38) | MAPTALDH1A1KDM4ENPSR1ALOX15 | |
| SCHEMBL1495328 | 0.73 | BRD4 (0.60) | MAPTALDH1A1LMNABRD4TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501703-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011060035-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |