Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCE | Q02156 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | MYLK | Q15746 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PRKCG | P05129 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 3/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1806510 | 0.88 | PDE4D (0.35) | HCAR2PDE4DMEN1KMT2AHSP90AA1 | |
| SCHEMBL1805134 | 0.86 | PDE4D (0.34) | PDE4D | |
| SCHEMBL1804792 | 0.84 | PARP1 (0.34) | HCAR2PDE4DALDH1A1CA12ALPL | |
| SCHEMBL1805098 | 0.81 | PDE4D (0.33) | HCAR2PDE4DMEN1KMT2ATTR | |
| SCHEMBL1809879 | 0.80 | XDH (0.34) | L3MBTL1HCAR2PDE4DALDH1A1CA12 | |
| SCHEMBL1803881 | 0.75 | HTR2A (0.34) | ALDH1A1 | |
| SCHEMBL1807102 | 0.73 | PDE4D (0.47) | POLBL3MBTL1PDE4DMEN1ALDH1A1 | |
| SCHEMBL1806149 | 0.66 | HCAR2 (0.42) | HCAR2CA12ALPLCA9 | |
| SCHEMBL12181094 | 0.66 | RXRA (0.44) | POLBL3MBTL1ALDH1A1CA12ALPL | |
| SCHEMBL27685454 | 0.64 | PTGS1 (0.40) | TDP1POLBL3MBTL1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501704-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011060217-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |