Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.53 |
| ▸ | MDM4 | O15151 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.47 |
| ▸ | CASP3 | P42574 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29843110 | 0.99 | PTPN1 (0.54) | PTPN1MDM4TP53SLC17A5MDM2 | |
| SCHEMBL29500417 | 0.99 | PTPN1 (0.54) | PTPN1MDM4TP53SLC17A5MDM2 | |
| SCHEMBL9732381 | 0.99 | PTPN1 (0.54) | PTPN1MDM4TP53SLC17A5MDM2 | |
| SCHEMBL24495215 | 0.90 | PTPN1 (0.52) | PTPN1MDM4TP53SLC17A5MDM2 | |
| SCHEMBL15083325 | 0.90 | MDM2 (0.52) | PTPN1MDM4TP53SLC17A5MDM2 | |
| SCHEMBL14584328 | 0.90 | FOLH1 (0.51) | PTPN1MDM4TP53SLC17A5MDM2 | |
| SCHEMBL24489613 | 0.90 | FOLH1 (0.51) | PTPN1MDM4TP53SLC17A5MDM2 | |
| SCHEMBL2578833 | 0.90 | CA2 (0.51) | PTPN1MDM4TP53SLC17A5MDM2 | |
| SCHEMBL21192400 | 0.90 | PTPN1 (0.52) | PTPN1MDM4TP53SLC17A5MDM2 | |
| SCHEMBL2030857 | 0.90 | FOLH1 (0.51) | PTPN1MDM4TP53SLC17A5MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3270949-A2 | INSULIN ANALOGUES CONTAINING A GLUCOSE-REGULATED CONFORMATIONAL SWITCH | Case Western Reserve University (US) | 2018-01-24 | — | — | EP | disclosed |
| WO-2016149222-A2 | INSULIN ANALOGUES CONTAINING A GLUCOSE-REGULATED CONFORMATIONAL SWITCH | CASE WESTERN RESERVE UNIVERSITY (US) | 2016-09-22 | — | — | WO | disclosed |