Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.54 |
| ▸ | MDM4 | O15151 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.48 |
| ▸ | CASP3 | P42574 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9732381 | 1.00 | PTPN1 (0.54) | PTPN1MDM4TP53SLC17A5MDM2 | |
| SCHEMBL29500417 | 1.00 | PTPN1 (0.54) | PTPN1MDM4TP53SLC17A5MDM2 | |
| Catechol SCHEMBL18074826 | 0.99 | PTPN1 (0.53) | PTPN1MDM4TP53SLC17A5MDM2 | |
| SCHEMBL24495215 | 0.91 | PTPN1 (0.52) | PTPN1MDM4TP53SLC17A5MDM2 | |
| SCHEMBL15083325 | 0.91 | MDM2 (0.52) | PTPN1MDM4TP53SLC17A5MDM2 | |
| SCHEMBL14584328 | 0.91 | FOLH1 (0.51) | PTPN1MDM4TP53SLC17A5MDM2 | |
| SCHEMBL24489613 | 0.91 | FOLH1 (0.51) | PTPN1MDM4TP53SLC17A5MDM2 | |
| SCHEMBL2578833 | 0.91 | CA2 (0.51) | PTPN1MDM4TP53SLC17A5MDM2 | |
| SCHEMBL21192400 | 0.91 | PTPN1 (0.52) | PTPN1MDM4TP53SLC17A5MDM2 | |
| SCHEMBL2030857 | 0.91 | FOLH1 (0.51) | PTPN1MDM4TP53SLC17A5MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4618968-A1 | MODULATORS OF PROTEASOME DYNAMICS AND/OR FUNCTION, COMPOSITIONS, METHODS, AND THERAPEUTIC USES THEREOF | Technion Research & Development Foundation Limited (IL) | 2025-09-24 | — | — | EP | disclosed |
| WO-2024105677-A1 | MODULATORS OF PROTEASOME DYNAMICS AND/OR FUNCTION, COMPOSITIONS, METHODS, AND THERAPEUTIC USES THEREOF | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2024-05-23 | — | — | WO | disclosed |
| CN-116406294-A | Tyrosine, tryptophan and phenylalanine as mTOR agonists modulating proteasome kinetics, compositions, methods and uses thereof in therapy, and methods of prognosis of drug resistance | 技术研发基金会有限公司 | 2023-07-07 | — | — | CN | disclosed |
| EP-4178563-A1 | TYROSINE, TRYPTOPHAN AND PHENYLALANINE AS MTOR AGONISTS MEDIATING PROTEASOME DYNAMICS, COMPOSITIONS, METHODS AND USES THEREOF IN THERAPY, AND PROGNOSTIC METHODS FOR DRUG-RESISTANCE | Technion Research & Development Foundation Ltd. (IL) | 2023-05-17 | — | — | EP | disclosed |
| WO-2022185319-A1 | UBIQUITIN LIGASE KPC1-PEPTIDE BASED PROTEOLYSIS TARGETING CHIMERAS (PROTAC) AND USES THEREOF | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2022-09-09 | — | — | WO | disclosed |