Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.49 |
| ▸ | PDE2A | O00408 | 4/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31255717 | 0.82 | MKNK1 (0.52) | MKNK1MKNK2IKBKBDHODHNPC1 | |
| SCHEMBL18076069 | 0.80 | MKNK1 (0.50) | MKNK1MKNK2PDE2APDE10APDE4A | |
| SCHEMBL29503858 | 0.76 | PLAU (0.53) | MKNK1MKNK2PLAUIKBKBNPC1 | |
| SCHEMBL1101140 | 0.76 | PLAU (0.53) | MKNK1MKNK2PLAUIKBKBNPC1 | |
| SCHEMBL27339338 | 0.75 | IKBKB (0.47) | IKBKBMAPK8CAMKK2 | |
| SCHEMBL7020144 | 0.75 | KDM4E (0.47) | MKNK1MKNK2IKBKB | |
| SCHEMBL18076044 | 0.74 | CCNC (0.47) | IKBKBPOLQ | |
| SCHEMBL17785403 | 0.73 | IKBKB (0.46) | PLAUIKBKBDHODHCCNT1CDK9 | |
| SCHEMBL30362791 | 0.73 | IKBKB (0.40) | PLAUIKBKBNPC1RAB9AFYN | |
| SCHEMBL14308482 | 0.71 | IKBKB (0.47) | MKNK1MKNK2PLAUIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10538491-B2 | 4,5-substituted picolinamide and picolinonitrile metabotropic glutamate receptor 2 negative allosteric modulators | VANDERBILT UNIVERSITY (US) | 2020-01-21 | — | — | US | disclosed |
| US-20180072674-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | VANDERBILT UNIVERSITY (US) | 2018-03-15 | — | — | US | disclosed |
| WO-2016149324-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | VANDERBILT UNIVERSITY (US) | 2016-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10538491-B2 | 4,5-substituted picolinamide and picolinonitrile metabotropic glutamate receptor 2 negative allosteric modulators | GRM2, GRIA2, GRIN2A | MKNK1 1881/4885MKNK2 1262/4885PDE2A 3067/4885 |
| US-20180072674-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | GRM2, GRM1, GRIN2A | MKNK1 1025/4885MKNK2 665/4885PDE2A 1827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.