Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 2/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MYC | P01106 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18076065 | 0.82 | MKNK1 (0.49) | MKNK1MKNK2P2RX7IKBKBNPC1 | |
| SCHEMBL14844649 | 0.79 | NOS3 (0.40) | MKNK1MKNK2IKBKBLIMK1KDM4E | |
| SCHEMBL15882337 | 0.78 | MKNK2 (0.39) | MKNK1MKNK2IKBKBLIMK1BTK | |
| SCHEMBL18076069 | 0.74 | MKNK1 (0.50) | MKNK1MKNK2P2RX7IKBKBDHODH | |
| SCHEMBL27399247 | 0.74 | MKNK1 (0.50) | MKNK1MKNK2P2RX7IKBKBLIMK1 | |
| SCHEMBL23067310 | 0.73 | MAP2K3 (0.50) | IKBKBBTKKDM4EADORA2AKMT2A | |
| SCHEMBL4560363 | 0.73 | MKNK1 (0.50) | MKNK1MKNK2IKBKBLIMK1KDM4E | |
| SCHEMBL31408890 | 0.72 | MAP2K3 (0.42) | MKNK1MKNK2IKBKBLIMK1LMNA | |
| SCHEMBL2931259 | 0.72 | MKNK1 (0.43) | MKNK1MKNK2P2RX7KDM4EMAPT | |
| SCHEMBL699068 | 0.71 | MKNK1 (0.49) | MKNK1MKNK2IKBKBLIMK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119317622-A | Compounds useful as TYK2 inhibitors, preparation method and application thereof in medicine | 上海致根医药科技有限公司 | 2025-01-14 | — | — | CN | disclosed |