SCHEMBL1807730

SCHEMBL1807730

CCCC(=O)O[C@]1(C(=O)COC(=O)CC)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](OC(=O)CC)C[C@@]21C

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGR P06401 5/20 0.68
AR P10275 3/20 0.68
CHRM1 P11229 2/20 0.68
NR3C2 P08235 7/20 0.68
NR3C1 P04150 3/20 0.68
HIF1A Q16665 8/20 0.62
KMT2A Q03164 2/20 0.62
SMN1; SMN2 Q16637 3/20 0.54
MAPT P10636 2/20 0.54
POLB P06746 1/20 0.54
GAA P10253 1/20 0.54
LMNA P02545 3/20 0.54
CYP3A4 P08684 2/20 0.54
USP2 O75604 1/20 0.54
CYP2D6 P10635 1/20 0.54
CYP2C9 P11712 1/20 0.54
HPGD P15428 1/20 0.52
MEN1 O00255 1/20 0.52
MLNR O43193 1/20 0.52
NR1I2 O75469 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1807731 0.97 PGR (0.70) PGRARCHRM1NR3C2NR3C1
SCHEMBL122186 0.92 NR3C2 (0.79) PGRARCHRM1NR3C2NR3C1
SCHEMBL110284 0.92 NR3C2 (0.69) PGRARCHRM1NR3C2NR3C1
Hydrocortisone Probutate SCHEMBL4290122 0.91 PGR (0.82) PGRARCHRM1NR3C2NR3C1
Hydrocortisone Probutate SCHEMBL4778 0.91 PGR (0.82) PGRARCHRM1NR3C2NR3C1
Hydrocortisone Probutate SCHEMBL14339602 0.91 PGR (0.82) PGRARCHRM1NR3C2NR3C1
Hydrocortisone Probutate SCHEMBL4280673 0.91 PGR (0.82) PGRARCHRM1NR3C2NR3C1
Hydrocortisone Probutate SCHEMBL30507561 0.91 PGR (0.82) PGRARCHRM1NR3C2NR3C1
SCHEMBL4290159 0.88 PGR (0.85) PGRARCHRM1NR3C2NR3C1
SCHEMBL122187 0.88 PGR (0.85) PGRARCHRM1NR3C2NR3C1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9314357-B2 Stent for placement in living body and stent delivery system TERUMO KABUSHIKI KAISHA (JP) 2016-04-19 US disclosed
EP-2444033-B1 STENT FOR PLACEMENT IN LIVING BODY, AND STENT DELIVERY SYSTEM TERUMO CORP (JP) 2015-01-28 EP disclosed
US-8518102-B2 Stent for placement in living body, and stent delivery system TERUMO KABUSHIKI KAISHA (JP) 2013-08-27 US disclosed
EP-2322121-B1 STENT FOR PLACEMENT IN LIVING BODY, AND STENT DELIVERY SYSTEM TERUMO CORP (JP) 2013-05-29 EP disclosed
US-20120158119-A1 STENT FOR PLACEMENT IN LIVING BODY AND STENT DELIVERY SYSTEM TERUMO KABUSHIKI KAISHA (JP) 2012-06-21 US disclosed
EP-2444033-A1 STENT FOR PLACEMENT IN LIVING BODY, AND STENT DELIVERY SYSTEM Terumo Kabushiki Kaisha (JP) 2012-04-25 EP disclosed
US-20110196475-A1 STENT FOR PLACEMENT IN LIVING BODY, AND STENT DELIVERY SYSTEM TERUMO KABUSHIKI KAISHA (JP) 2011-08-11 US disclosed
EP-2322121-A1 STENT FOR PLACEMENT IN LIVING BODY, AND STENT DELIVERY SYSTEM Terumo Kabushiki Kaisha (JP) 2011-05-18 EP disclosed