Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16474482 | 0.89 | PDK2 (0.46) | MCHR1HRH3PDK2KCNH2MEN1 | |
| SCHEMBL18077752 | 0.86 | PDK2 (0.45) | MCHR1HRH3PDK2KCNH2PLA2G7 | |
| SCHEMBL18077753 | 0.86 | MCHR1 (0.42) | MCHR1HRH3KCNH2PLA2G7MAPK14 | |
| SCHEMBL18812016 | 0.86 | PDK2 (0.51) | PDK2MEN1KMT2ACCNCCDK8 | |
| SCHEMBL18077712 | 0.83 | MCHR1 (0.53) | MCHR1HRH3KCNH2MAPK14 | |
| SCHEMBL18077683 | 0.81 | HRH3 (0.46) | MCHR1HRH3KCNH2MAPK14 | |
| SCHEMBL18812149 | 0.77 | FFAR4 (0.42) | — | |
| SCHEMBL2893479 | 0.77 | MCHR1 (0.54) | MCHR1HRH3PDK2KCNH2MEN1 | |
| SCHEMBL2891140 | 0.77 | MCHR1 (0.54) | MCHR1HRH3PDK2KCNH2MEN1 | |
| SCHEMBL16474536 | 0.76 | PDK2 (0.53) | MCHR1PDK2CCNCCDK8CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160263090-A1 | ANTI-FIBROTIC PYRIDINONES | GENENTECH, INC. | 2016-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160263090-A1 | ANTI-FIBROTIC PYRIDINONES | MMP1, COL1A1, COL2A1 | MCHR1 4671/4885HRH3 914/4885PDK2 1258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.