Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.53 |
| ▸ | IDO1 | P14902 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TTK | P33981 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5313793 | 0.77 | KDM4A (0.42) | ALDH1A1KDM4ERAB9ASMN1; SMN2MEN1 | |
| SCHEMBL4245215 | 0.77 | ROCK1 (0.57) | ALDH1A1KDM4ERAB9ASMN1; SMN2MEN1 | |
| SCHEMBL1672674 | 0.74 | IDO1 (0.78) | ALDH1A1KDM4ERAB9ALRRK2IDO1 | |
| SCHEMBL5772080 | 0.74 | KDM4E (0.60) | ALDH1A1KDM4ERAB9ASMN1; SMN2MEN1 | |
| SCHEMBL2870463 | 0.73 | LRRK2 (0.59) | ALDH1A1KDM4ELRRK2IDO1GAA | |
| SCHEMBL18038340 | 0.72 | LRRK2 (0.54) | ALDH1A1KDM4ERAB9ASMN1; SMN2MEN1 | |
| SCHEMBL21658872 | 0.72 | KDM4E (0.53) | ALDH1A1KDM4ERAB9ALRRK2IDO1 | |
| SCHEMBL11772208 | 0.72 | LRRK2 (0.58) | ALDH1A1KDM4ERAB9ASMN1; SMN2LRRK2 | |
| SCHEMBL1800635 | 0.71 | MEN1 (1.00) | ALDH1A1KDM4ERAB9ASMN1; SMN2MEN1 | |
| SCHEMBL4888531 | 0.71 | LRRK2 (0.53) | ALDH1A1KDM4ERAB9ALRRK2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951814-B2 | Quinazolinedione derivatives as TRPA1 modulators | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2011-05-31 | — | — | US | disclosed |
| WO-2010004390-A1 | QUINAZOLINE DIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-01-14 | — | — | WO | disclosed |
| US-20090325987-A1 | QUINAZOLINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325987-A1 | QUINAZOLINEDIONE DERIVATIVES AS TRPA1 MODULATORS | TRPA1, TRPV1, TRPC3 | ALDH1A1 871/4885KDM4E 4660/4885RAB9A 2497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.