Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.33 |
| ▸ | HRH2 | P25021 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11898578 | 0.86 | GPR119 (0.38) | HSP90AA1HSP90AB1KDM4EALDH1A1CA12 | |
| SCHEMBL1804229 | 0.85 | CA12 (0.36) | HSP90AA1HSP90AB1CA12CA1CA9 | |
| SCHEMBL15166573 | 0.69 | LMNA (0.48) | LMNAPOLBSMN1; SMN2SMYD3HRH2 | |
| SCHEMBL30598434 | 0.69 | NPC1 (0.46) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL556212 | 0.69 | MMP1 (0.37) | MMP13CA12CA1CA9 | |
| SCHEMBL557260 | 0.69 | ESR2 (0.51) | KMT2AKDM4E | |
| SCHEMBL29598912 | 0.68 | LMNA (0.49) | LMNAPOLBSMN1; SMN2SMYD3HRH2 | |
| SCHEMBL5156097 | 0.68 | NR1H2 (0.41) | SMN1; SMN2KMT2AKDM4E | |
| SCHEMBL1445031 | 0.67 | LMNA (0.48) | LMNAPOLBSMN1; SMN2SMYD3PLA2G2A | |
| SCHEMBL10097950 | 0.67 | LMNA (0.48) | LMNAPOLBSMN1; SMN2SMYD3HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488530-A1 | SPIROCYCLIC PIPERIDINE DERIVATIVES USEFUL AS RENIN INHIBITORS | Merck Canada Inc. (CA) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011057382-A1 | SPIROCYCLIC PIPERIDINE DERIVATIVES USEFUL AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2011-05-19 | — | — | WO | disclosed |