Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG2 | P78540 | 14/20 | 0.48 |
| ▸ | ARG1 | P05089 | 13/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10006260 | 0.93 | ARG1 (0.58) | ARG2ARG1 | |
| SCHEMBL18079487 | 0.88 | ARG2 (0.43) | ARG2ARG1SIGMAR1 | |
| SCHEMBL18079469 | 0.85 | ARG1 (0.54) | ARG2ARG1 | |
| SCHEMBL10006164 | 0.81 | ARG1 (0.52) | ARG2ARG1SIGMAR1 | |
| SCHEMBL18079494 | 0.80 | ARG1 (0.40) | ARG2ARG1SIGMAR1MAPK1 | |
| SCHEMBL18079492 | 0.78 | ATM (0.44) | ARG2ARG1SIGMAR1MAPK1 | |
| SCHEMBL18079470 | 0.78 | ARG1 (0.57) | ARG2ARG1 | |
| SCHEMBL10006499 | 0.78 | ARG1 (0.65) | ARG2ARG1 | |
| SCHEMBL18079486 | 0.76 | ARG2 (0.46) | ARG2ARG1SIGMAR1 | |
| SCHEMBL18079473 | 0.75 | ARG2 (0.47) | ARG2ARG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447122-B2 | Arginase inhibitors and methods of use thereof | ASTRAZENECA AB (SE) | 2016-09-20 | — | — | US | disclosed |