Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 6/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | ARG1 | P05089 | 8/20 | 0.39 |
| ▸ | ARG2 | P78540 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10006244 | 0.94 | ARG2 (0.46) | ATMLTA4HHTR2ASLC6A4TMEM97 | |
| SCHEMBL18079487 | 0.90 | ARG2 (0.43) | ATMTMEM97SIGMAR1ARG1ARG2 | |
| SCHEMBL18079494 | 0.88 | ARG1 (0.40) | ATMTMEM97SIGMAR1ARG1ARG2 | |
| SCHEMBL18079486 | 0.84 | ARG2 (0.46) | LTA4HTMEM97SIGMAR1ARG1ARG2 | |
| SCHEMBL10006164 | 0.83 | ARG1 (0.52) | SIGMAR1ARG1ARG2 | |
| SCHEMBL10006086 | 0.81 | ARG2 (0.48) | TMEM97SIGMAR1ARG1ARG2 | |
| SCHEMBL18079490 | 0.79 | ARG1 (0.44) | TMEM97SIGMAR1ARG1ARG2 | |
| SCHEMBL18079472 | 0.79 | TMEM97 (0.44) | TMEM97SIGMAR1ARG1ARG2 | |
| SCHEMBL18079474 | 0.78 | ARG2 (0.48) | SIGMAR1ARG1ARG2MAPK1 | |
| SCHEMBL10006166 | 0.77 | ARG1 (0.55) | ARG1ARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447122-B2 | Arginase inhibitors and methods of use thereof | ASTRAZENECA AB (SE) | 2016-09-20 | — | — | US | disclosed |