SCHEMBL18079667

SCHEMBL18079667

Cc1ccc(NC(=O)NC(C)(C)c2cccc(-c3ccccc3)c2)cc1

nearest known ligand 0.65

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.53
MAPT P10636 1/20 0.53
ALDH1A1 P00352 1/20 0.50
MGLL Q99685 1/20 0.48
CNR1 P21554 5/20 0.47
PTPN5 P54829 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2607688 0.88 RAB9A (0.50) LMNAMAPTALDH1A1CNR1
Daimuron SCHEMBL1860112 0.87 NPC1 (0.51) LMNAMAPTALDH1A1
Daimuron SCHEMBL65275 0.87 NPC1 (0.51) LMNAMAPTALDH1A1
SCHEMBL2607704 0.84 SMN1; SMN2 (0.52) MAPTCNR1
SCHEMBL16624879 0.84 CNR1 (0.48) CNR1
SCHEMBL13182228 0.84 POLB (0.57) LMNAMAPTCNR1
SCHEMBL2607590 0.82 LMNA (0.44) LMNAMAPTMGLL
SCHEMBL2607504 0.82 MAPT (0.73) LMNAMAPTALDH1A1
SCHEMBL17924791 0.81 RXRA (0.53) MGLLPTPN5
SCHEMBL7904977 0.80 RAB9A (0.52) LMNAMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9447134-B2 Compounds and methods for treating mammalian gastrointestinal microbial infections BRANDEIS UNIVERSITY (US) 2016-09-20 US disclosed