Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.68 |
| ▸ | MAPT | P10636 | 7/20 | 0.68 |
| ▸ | NPC1 | O15118 | 5/20 | 0.68 |
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | GAA | P10253 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18079704 | 0.85 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTNPC1RAB9AGAA | |
| SCHEMBL16155536 | 0.85 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPTNPC1RAB9AGAA | |
| SCHEMBL18079702 | 0.77 | SLC1A2 (0.71) | SMN1; SMN2MAPTNPC1RAB9AGAA | |
| SCHEMBL6403236 | 0.70 | MAPK1 (0.62) | SMN1; SMN2MAPTNPC1RAB9AKMT2A | |
| SCHEMBL4215001 | 0.70 | ALDH1A1 (0.71) | SMN1; SMN2MAPTNPC1RAB9AKMT2A | |
| SCHEMBL18079705 | 0.70 | SLC1A2 (0.68) | SMN1; SMN2MAPTNPC1RAB9AGAA | |
| SCHEMBL18080851 | 0.69 | SLC1A2 (0.67) | SMN1; SMN2MAPTNPC1RAB9AGAA | |
| SCHEMBL6402415 | 0.69 | ALDH1A1 (0.74) | SMN1; SMN2MAPTNPC1RAB9APKM | |
| SCHEMBL16155539 | 0.69 | RAB9A (0.45) | SMN1; SMN2MAPTNPC1RAB9AGAA | |
| SCHEMBL1743044 | 0.69 | CYP2A6 (0.56) | SMN1; SMN2MAPTNPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447075-B2 | Pyridazine derivatives as EAAT2 activators | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2016-09-20 | — | — | US | disclosed |
| US-9447075-B2 | Pyridazine derivatives as EAAT2 activators | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2016-09-20 | — | — | US | disclosed |